Recombinant Rat SV2B Protein
| 货号： | GXP83071 |
|---|---|
| Swiss Prot： | Q63564 |
| 种属： | Rat |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 1–683aa |
| 标签： | Customize |
| 纯度： | >90% |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
价格：¥2580
货期：3-4周/weeks
规格：
说明书：
产品详情
| 产品名称： | Recombinant Rat SV2B Protein |
|---|---|
| 别名： | Sv2b Sv2bb |
| 货号： | GXP83071 |
| Swiss Prot： | Q63564 |
| 种属： | Rat |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 1–683aa |
| 标签： | Customize |
| 纯度： | >90% |
| 实际分子量： | Depends On Tags |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
| 无载体： | Yes |
| 无动物源： | Yes |
| 制剂： | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| 描述： | Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.; (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds via extracellular loop 4 (PubMed:16543415). Restores uptake of BoNT/A in mouse and rat cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:18815274, PubMed:19650874). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119). {ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:18815274, ECO:0000269|PubMed:19650874, ECO:0000269|PubMed:29649119}.; (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541). {ECO:0000269|PubMed:21483489, ECO:0000269|PubMed:21632541}.; (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). Restores uptake of BoNT/E in mouse cells that are deleted for SV2 receptor (PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:19650874). {ECO:0000269|PubMed:18815274, ECO:0000269|PubMed:19650874}.; (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of this protein (PubMed:19476346, PubMed:19650874). {ECO:0000269|PubMed:19650874, ECO:0000305|PubMed:19476346}. |
| 活性测试： | Not Test |
| 复溶： |
Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. 收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。 |
| 储存： |
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. 未开盖的干粉蛋白在 -20°C至-80°C可保存12个月； 复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。 |
