Recombinant Mouse THA11 Protein
| 货号： | GXP57692 |
|---|---|
| Swiss Prot： | Q9JJD0 |
| 种属： | Mouse |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 1–305aa |
| 标签： | Customize |
| 纯度： | >90% |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
价格：¥2580
货期：3-4周/weeks
规格：
说明书：
产品详情
| 产品名称： | Recombinant Mouse THA11 Protein |
|---|---|
| 别名： | Thap11 MNCb-2032 |
| 货号： | GXP57692 |
| Swiss Prot： | Q9JJD0 |
| 种属： | Mouse |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 1–305aa |
| 标签： | Customize |
| 纯度： | >90% |
| 实际分子量： | Depends On Tags |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
| 无载体： | Yes |
| 无动物源： | Yes |
| 制剂： | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| 描述： | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (PubMed:18585351). Required for normal brain development and neural precursor differentiation (By similarity). {ECO:0000250|UniProtKB:Q6TGZ4, ECO:0000269|PubMed:18585351}.; Transcription factor, which has both transcriptional activation and repression activities (PubMed:18585351, PubMed:26876175, PubMed:34515391). Also modulates chromatin accessibility (By similarity). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (By similarity). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (PubMed:34515391). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (PubMed:26876175, PubMed:34515391). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (PubMed:18585351, PubMed:34515391). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (PubMed:26876175). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (By similarity). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (By similarity). {ECO:0000250|UniProtKB:Q6TGZ4, ECO:0000250|UniProtKB:Q96EK4, ECO:0000269|PubMed:18585351, ECO:0000269|PubMed:26876175, ECO:0000269|PubMed:34515391}. |
| 活性测试： | Not Test |
| 复溶： |
Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. 收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。 |
| 储存： |
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. 未开盖的干粉蛋白在 -20°C至-80°C可保存12个月； 复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。 |
