Recombinant Mouse GRIK2 Protein
| 货号： | GXP51804 |
|---|---|
| Swiss Prot： | P39087 |
| 种属： | Mouse |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 32–908aa |
| 标签： | Customize |
| 纯度： | >90% |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
价格：¥2580
货期：3-4周/weeks
规格：
说明书：
产品详情
| 产品名称： | Recombinant Mouse GRIK2 Protein |
|---|---|
| 别名： | Grik2 Glur6 |
| 货号： | GXP51804 |
| Swiss Prot： | P39087 |
| 种属： | Mouse |
| 表达宿主： | E. Coli / 293F |
| 表达区间： | 32–908aa |
| 标签： | Customize |
| 纯度： | >90% |
| 实际分子量： | Depends On Tags |
| 内毒素： | < 1.0 EU/μg / < 0.1 EU/μg |
| 无载体： | Yes |
| 无动物源： | Yes |
| 制剂： | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| 描述： | Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17620617, PubMed:19217376, PubMed:20007474, PubMed:31474366, PubMed:7681676). Modulates cell surface expression of NETO2 (PubMed:19217376). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (PubMed:17620617). {ECO:0000269|PubMed:17620617, ECO:0000269|PubMed:19217376, ECO:0000269|PubMed:20007474, ECO:0000269|PubMed:31474366, ECO:0000269|PubMed:7681676}.; Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (PubMed:31474366). {ECO:0000269|PubMed:31474366}.; [Isoform GluR6-2]: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. {ECO:0000269|PubMed:1379666}. |
| 活性测试： | ACTIVITY REGULATION: Cold receptor activity activated by temperatures between 10-19 degrees Celsius. {ECO:0000269|PubMed:31474366}. |
| 复溶： |
Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. 收到重组蛋白产品之后请检查蛋白冻干粉末是否贴于瓶底，如果粉末浮起，开盖之前请先低温离心。将蛋白用说明书中指定的缓冲液复溶至0.1-0.5 mg/mL（请注意蛋白复溶浓度不能低于0.1 mg/mL），室温平衡5-10 min保证充分溶解，复溶过程中请不要剧烈涡旋及吹打蛋白溶液。如需长期储存，建议复溶时添加载体蛋白或者稳定剂（如0.1% BSA, 5% HSA, 10% FBS 或者 5% 海藻糖），同时将复溶后的蛋白溶液按照需求进行分装，储存于-20°C至-80°C，随取随用，避免反复冻融。 |
| 储存： |
Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. 未开盖的干粉蛋白在 -20°C至-80°C可保存12个月； 复溶之后，蛋白溶液在-20°C及以下可保存3个月，在2-8℃可保存1周。 |
